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Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
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Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels

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STIM1 is a calcium sensor specialized for digital signaling

Gary S Bird1, Sung-Yong Hwang, Jeremy T Smyth

  • 1Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

Current Biology : CB
|September 22, 2009
PubMed
Summary

Stromal interaction molecule 1 (STIM1) exclusively mediates calcium entry during cellular calcium oscillations, not STIM2. This finding reveals a precise signaling mechanism for translating digital calcium release into cellular influx.

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