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Increased lipoprotein lipase activity in non-small cell lung cancer tissue predicts shorter patient survival
Zoran Trost1, Miha Sok, Janja Marc
1Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Background And Aims:
Cumulative evidence suggests the involvement of lipoprotein lipase (LPL) in tumor progression. We tested the hypothesis that increased LPL activity in resectable non-small cell lung cancer (NSCLC) tissue and the increased LPL gene expression in the surrounding non-cancer lung tissue found in our previous study are predictors of patient survival.
Methods:
Forty two consecutive patients with resected NSCLC were enrolled in the study. Paired samples of lung cancer tissue and adjacent non-cancer lung tissue were collected from resected specimens for baseline LPL activity and gene expression estimation. During a 4-year follow-up, 21 patients died due to tumor progression. One patient died due to a non-cancer reason and was not included in Cox regression analysis.
Results:
High LPL activity in cancer tissue (relative to the adjacent non-cancer lung tissue) predicted shorter survival, independently of standard prognostic factors (p=0.003). High gene expression in the non-cancer lung tissue surrounding the tumor had no predictive value.
Conclusions:
Our study further underlines the involvement of cancer tissue LPL activity in tumor progression.
