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[Hyperhomocysteinemia and cardiometabolic risk]
Helio Vannucchi1, Sandra Soares Melo
1Divisão de Nutrologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP) Av. Bandeirantes, 3.900 14049-900 - Ribeirão Preto, SP, Brasil. hvannucc@fmrp.usp.br
Arquivos Brasileiros De Endocrinologia E Metabologia
|September 22, 2009
Summary
High homocysteine levels (hyperhomocysteinemia) are linked to vascular diseases. This review examines the relationship, genetic and nutritional factors, and potential treatments like B vitamins.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Nutritional Science
Context:
- Hyperhomocysteinemia is a debated causal factor in vascular diseases.
- Numerous studies confirm a link between elevated homocysteine and vascular pathology.
- Understanding this link is crucial for cardiovascular health.
Purpose:
- To review the interrelation between plasma homocysteine concentrations and vascular diseases.
- To explore the role of genetic and nutritional factors in hyperhomocysteinemia.
- To elucidate the mechanisms and treatments of this condition.
Summary:
- This review synthesizes research from 1962-2009 on hyperhomocysteinemia and vascular disease.
- It investigates genetic mutations affecting homocysteine metabolism and nutritional deficiencies (B vitamins).
- Mechanisms like endothelial dysfunction and lipid peroxidation are implicated, though not fully clarified.
Impact:
- Highlights the significance of homocysteine levels as a vascular risk factor.
- Emphasizes the role of genetic predispositions and nutritional status.
- Suggests folic acid and B vitamins (B6, B12) as key treatments for hyperhomocysteinemia.
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