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[Hyperhomocysteinemia and cardiometabolic risk]

Helio Vannucchi1, Sandra Soares Melo

  • 1Divisão de Nutrologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP) Av. Bandeirantes, 3.900 14049-900 - Ribeirão Preto, SP, Brasil. hvannucc@fmrp.usp.br

Arquivos Brasileiros De Endocrinologia E Metabologia
|September 22, 2009
PubMed

Insights

High homocysteine levels (hyperhomocysteinemia) are linked to vascular diseases. This review examines the relationship, genetic and nutritional factors, and potential treatments like B vitamins.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Nutritional Science

Context:

  • Hyperhomocysteinemia is a debated causal factor in vascular diseases.
  • Numerous studies confirm a link between elevated homocysteine and vascular pathology.
  • Understanding this link is crucial for cardiovascular health.

Purpose:

  • To review the interrelation between plasma homocysteine concentrations and vascular diseases.
  • To explore the role of genetic and nutritional factors in hyperhomocysteinemia.
  • To elucidate the mechanisms and treatments of this condition.

Summary:

  • This review synthesizes research from 1962-2009 on hyperhomocysteinemia and vascular disease.
  • It investigates genetic mutations affecting homocysteine metabolism and nutritional deficiencies (B vitamins).
  • Mechanisms like endothelial dysfunction and lipid peroxidation are implicated, though not fully clarified.

Impact:

  • Highlights the significance of homocysteine levels as a vascular risk factor.
  • Emphasizes the role of genetic predispositions and nutritional status.
  • Suggests folic acid and B vitamins (B6, B12) as key treatments for hyperhomocysteinemia.

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