Related Experiment Video
Updated: Jun 20, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
[Role of dietary lipids in diabetic nephropathy]
Jussara C de Almeida1, Vanessa D de Mello, Luis H Canani
1Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Abstract:
The aim of the present study was to review the possible role of dietary lipids in diabetic nephropathy (DN), taking into account associated abnormalities of serum lipids and interaction of dietary and genetic aspects. Dietary lipids may have an important role in the development and progression of DN. The fat diet composition has been associated with DN, particularly with microalbuminuria, serum lipids abnormalities, and endothelial function. However, the beneficial effect of fat intake modification for these patients is not fully established, especially regarding hard outcomes, such as DN incidence and progression, kidney failure, and death. Moreover, genetic factors may influence the response of serum lipids to fat intake. The identification of specific genetic polymorphisms associated with this interaction could allow adoption of individual nutritional strategies in DN.
Related Concept Videos
Diabetic Nephropathy
Diabetic Neuropathy
Diabetic Retinopathy
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease II: Clinical Manifestations
Nephrotic Syndrome I : Introduction