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Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
DNA vaccines against influenza viruses
1Department of Microbiology & Immunology and Emory Vaccine Center, School of Medicine, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.
Abstract:
As an attractive alternative to conventional vaccines, DNA vaccines play a critical role in inducing protection against several infectious diseases. In this review, we discuss the advantages that DNA vaccines offer in comparison to conventional protein-based vaccines. We discuss strategies to improve the potency and efficacy of DNA vaccines. Specifically, we focus on the potential use of DNA-based vaccines to elicit broad-spectrum humoral and cellular immunity against influenza virus. Finally, we discuss the advances made in the use of DNA vaccines to prevent avian H5N1 influenza.
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