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Updated: Jun 20, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
Translating health care-associated urinary tract infection prevention research into practice via the bladder bundle
Sanjay Saint1, Russell N Olmsted, Mohamad G Fakih
1VA Ann Arbor HSR&D Center of Excellence, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA. saint@med.umich.edu
Insights
Catheter-associated urinary tract infections (CAUTIs) are a significant burden. The MHA Keystone HAI initiative implements a bladder bundle to optimize urinary catheter use and reduce infection rates.
Area of Science:
- Healthcare-associated infections
- Patient safety research
- Clinical practice improvement
Background:
- Catheter-associated urinary tract infection (CAUTI) is a common and costly healthcare-associated infection (HAI).
- CAUTI leads to patient discomfort, restricted activity, and delayed hospital discharge.
- CMS no longer reimburses hospitals for CAUTI-related costs, increasing financial strain.
Purpose of the Study:
- To evaluate the MHA Keystone HAI statewide initiative aimed at reducing CAUTI.
- To identify practical strategies for effective implementation of infection prevention practices.
- To bridge the gap between research evidence and bedside clinical practice.
Main Methods:
- The MHA Keystone HAI initiative utilizes a 'bladder bundle' approach.
- This bundle emphasizes optimizing urinary catheter use and timely removal.
- A collaborative effort between researchers and a statewide patient safety organization employs mixed methods.
Main Results:
- The initiative focuses on preventing CAUTI through careful catheter assessment and removal.
- Collaboration aims to translate evidence-based practices into clinical settings.
- Development and testing of practical implementation strategies are ongoing.
Conclusions:
- Disseminating evidence alone is insufficient to change clinical practice.
- Effective implementation strategies are crucial for improving care quality and safety.
- Learning how to implement findings is critical for promoting high-quality, safe healthcare environments.
Background:
Catheter-associated urinary tract infection (CAUTI), a frequent health care-associated infection (HAI), is a costly and common condition resulting in patient discomfort, activity restriction, and hospital discharge delays. The Centers for Medicare & Medicaid Services (CMS) no longer reimburses hospitals for the extra cost of caring for patients who develop CAUTI. The Michigan Health and Hospital Association (MHA) Keystone Center for Patient Safety & Quality has initiated a statewide initiative, MHA Keystone HAI, to help ameliorate the burden of disease associated with indwelling catheterization. In addition, a long-term research project is being conducted to evaluate the current initiative and to identify practical strategies to ensure the effective use of proven infection prevention and patient safety practices.
Overview Of The Bladder Bundle Initiative In Michigan:
The bladder bundle as conceived by MHA Keystone HAI focuses on preventing CAUTI by optimizing the use of urinary catheters with a specific emphasis on continual assessment and catheter removal as soon as possible, especially for patients without a clear indication. COLLABORATION BETWEEN RESEARChERS AND STATE WIDE PATIENT SAFETY ORGANIZATIONS: A synergistic collaboration between patient safety researchers and a statewide patient safety organization is aimed at identifying effective strategies to move evidence from peer-reviewed literature to the bedside. Practical strategies that facilitate implementation of the bundle will be developed and tested using mixed quantitative and qualitative methods.
Discussion:
Simply disseminating scientific evidence is often ineffective in changing clinical practice. Therefore, learning how to implement these findings is critically important to promoting high-quality care and a safe health care environment.
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