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Bioprinted nanoparticles for tissue engineering applications.

Kivilcim Buyukhatipoglu1, Robert Chang, Wei Sun

  • 1Mechanical Engineering and Mechanics Department, Drexel University, Philadelphia, PA, USA.

Tissue Engineering. Part C, Methods
|September 23, 2009
PubMed
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This study introduces a hybrid nanobioprinting technique for precise cell and bioactive factor manipulation in tissue engineering. The method uses superparamagnetic nanoparticles for noninvasive tracking and external magnetic fields for active patterning within scaffolds.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Precise control over cell and bioactive factor placement is crucial for advanced tissue engineering scaffolds.
  • Existing methods may lack the dynamic manipulation and tracking capabilities needed for complex 3D constructs.

Purpose of the Study:

  • To develop and evaluate a novel hybrid nanobioprinting technique combining syringe deposition and superparamagnetic nanoparticle manipulation.
  • To assess the viability and tracking capabilities of cells and factors within engineered tissues using this method.

Main Methods:

  • A hybrid nanobioprinting approach was developed using syringe-based deposition and superparamagnetic iron oxide nanoparticles (SPIONs).
  • SPIONs were incorporated into alginate biopolymer or loaded into endothelial cells.

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  • Cell viability was assessed post-bioprinting, and nanoparticle manipulation was achieved using external magnetic fields and imaged via microcomputed tomography.

    • Main Results:

    • Bioprinting with SPIONs in alginate showed dose-dependent decreases in cell viability.
    • Loading SPIONs into cells significantly reduced viability, with further reduction upon bioprinting.
    • Cell viability stabilized after an initial toxicity effect, and nanoparticles were successfully manipulated and tracked using magnetic fields.

    Conclusions:

    • The hybrid nanobioprinting technique enables noninvasive manipulation and tracking of cells and bioactive factors within 3D tissue constructs.
    • This method offers potential for enhanced control in tissue engineering applications.
    • Further optimization is needed to mitigate nanoparticle-induced cytotoxicity.