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Published on: December 18, 2013
Temperature-dependent proteolysis as a control element in Escherichia coli metabolism
Chen Katz1, Aviram Rasouly, Eyal Gur
1Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Levanon St, Tel Aviv 69978, Israel.
Abstract:
Escherichia coli can grow at a broad temperature range, from less than 20 degrees C up to 45 degrees C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.
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