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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: Jun 20, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Published on: April 11, 2025

Gray matter changes related to chronic posttraumatic headache.

Mark Obermann1, K Nebel, C Schumann

  • 1Department of Neurology, University of Duisburg-Essen, 45122 Essen, Germany. mark.obermann@uni-due.de

Neurology
|September 23, 2009
PubMed
Summary
This summary is machine-generated.

Chronic headache after whiplash injury involves adaptive brain changes. Gray matter decreases in certain areas resolved, while pain-processing centers showed increased gray matter, indicating neuronal plasticity.

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Last Updated: Jun 20, 2026

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

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Published on: April 11, 2025

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
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Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
09:07

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Published on: September 28, 2022

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Pain Research

Background:

  • Whiplash injury can lead to chronic headache in up to 15% of patients.
  • The underlying mechanisms of post-traumatic headache remain poorly understood.

Purpose of the Study:

  • To investigate brain structural changes in patients with post-traumatic headache following whiplash injury.
  • To explore the relationship between these changes and headache chronicity.

Main Methods:

  • Magnetic resonance-based voxel-based morphometry was used to assess gray matter changes.
  • Thirty-two patients with post-traumatic headache were studied at 14 days, 3 months, and 1 year post-injury.

Main Results:

  • Patients developing chronic headache showed decreased gray matter in the anterior cingulate and dorsolateral prefrontal cortex at 3 months.
  • These gray matter decreases resolved by 1 year, coinciding with headache cessation.
  • The same patients exhibited increased gray matter in pain-processing brainstem centers, thalamus, and cerebellum at 1 year.

Conclusions:

  • Adaptive gray matter changes in pain-processing structures suggest neuronal plasticity in chronic post-traumatic headache.
  • These findings provide a biological basis for understanding this disabling condition.