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Updated: Jun 20, 2026
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
Patterns of recurrence after curative-intent radiation for oligometastases confined to one organ
Michael T Milano1, Alan W Katz, Paul Okunieff
1Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA. mtmilano@yahoo.com
Objectives:
We sought to characterize and describe the patterns of distant recurrence in patients with macroscopic oligometastases, limited in number (
Methods:
Seventy-seven patients enrolled on prospective studies of SBRT for oligometastases are included in the present analysis. All available radiography and records were retrospectively reviewed to determine the timing and location of recurrences.
Results:
New metastases occurred in 73% of patients. Among these patients, new metastases developed most frequently in the same organ (occurring in 82% of first new metastases after SBRT and 89% of cumulative new metastases). Metastases to other organs were common as well (occurring cumulatively in 79% of patients). In patients with liver oligometastases, common sites of further progression included the liver, other abdominal organs, and lungs. In patients with lung oligometastases, common sites of further progression included the lungs, thoracic lymph nodes, bones, liver, and brain.
Conclusions:
Patients receiving SBRT for oligometastases confined to one organ are apt to develop new metastases, most frequently occurring in the initially involved organ, but also commonly in other organs. A subset of patients remains disease free after extended follow-up.
