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[Cavinton in the complex treatment of patients with chronic cerebrovascular insufficiency]

E I Chukanova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |September 23, 2009
    PubMed

    Insights

    Cavinton improved neurological function in patients with discirculatory encephalopathy (DE). This treatment significantly reduced the risk of DE progression, transient ischemic attacks, and strokes compared to standard therapy.

    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Discirculatory encephalopathy (DE) is a condition affecting brain function due to impaired blood flow.
    • Effective treatment strategies for DE are crucial for improving patient outcomes and preventing neurological deficits.

    Purpose of the Study:

    • To evaluate the efficacy of Cavinton as an add-on therapy for patients with discirculatory encephalopathy.
    • To assess the impact of Cavinton on neurological status, cognitive function, and the risk of cerebrovascular events in DE patients.

    Main Methods:

    • A clinical study involving 138 patients with DE treated with Cavinton (30 mg/day for 90 days, twice yearly) plus basic therapy.
    • A control group of 98 patients received only basic therapy (hypotensive, antithrombotic drugs, glycine).
    • Neurological and neuropsychological assessments were conducted at baseline and at 3, 6, and 12 months.

    Main Results:

    • Patients receiving Cavinton showed significant improvement in neurological syndromes compared to the control group over 12 months.
    • Cavinton treatment led to a substantial reduction in the risk of DE progression (relative risk 0.01).
    • The risk of transient ischemic attacks and strokes was significantly decreased in the Cavinton group (relative risk 0.14).

    Conclusions:

    • Complex therapy including Cavinton is effective in managing discirculatory encephalopathy.
    • Cavinton demonstrates a significant protective effect against the progression of DE and cerebrovascular events like strokes.

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