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Updated: Jun 20, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Platinum(II) mediated C(sp3)-H activation of tetramethylthiourea
Serena Fantasia1, Alessandro Pasini, Steven P Nolan
1Dipartimento di Chimica Inorganica, Metallorganica e Analitica, Universitá degli Studi di Milano, Via Venezian 21, 20133, Milan, Italy.
Abstract:
The C-H activation of the methyl group of tetramethylthiourea by cis-[PtL(2)(NO(3))(2)] (L = phosphine or N-heterocyclic carbene) has been investigated as a function of the ligand L. The presence of an electron-withdrawing group on the tertiary phosphine was found to promote the process. Moreover, when an excess of nitrate anion is present in the reaction mixture, the rate of C-H bond activation is retarded, suggesting the key role of an unsaturated tri-coordinate Pt(II) species as intermediate.
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