MHC class II regulation by epigenetic agents and microRNAs

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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
11:06

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

Thomas B Tomasi1, William J Magner, Jennifer L Wiesen

  • 1Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. thomas.tomasi@roswellpark.org

Immunologic Research
|September 23, 2009
PubMed

Insights

Stress impacts microRNAs (miRNAs), small molecules that regulate gene expression. This review explores how stress affects miRNAs and immune genes, noting Dicer enzyme alterations during immune disorder treatments.

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression at transcriptional and translational levels.
  • Stressors can alter cellular miRNA profiles.
  • Immune gene regulation is complex and influenced by various factors.

Purpose of the Study:

  • To review evidence linking various stresses to miRNA regulation of immune gene expression.
  • To investigate how Dicer enzyme expression is affected by treatments for immune disorders.
  • To discuss potential signaling pathways regulating Dicer and miRNA levels.

Main Methods:

  • Literature review of studies examining miRNA levels under stress and in disease.
  • Analysis of research on Dicer expression changes in response to therapeutic agents.
  • Discussion of relevant signal transduction pathways.

Main Results:

  • Evidence shows stress alters miRNA levels in normal cells and disease states like cancer.
  • Unexpectedly, Dicer expression is modified by treatments such as interferons and cortisone.
  • Potential regulatory pathways including JAK/Stat, PI3K, and PKR are identified.

Conclusions:

  • Stress-induced changes in miRNAs significantly impact immune gene expression.
  • Dicer modulation by immune disorder treatments highlights a novel regulatory mechanism.
  • Understanding these pathways is crucial for therapeutic development in immune-related conditions.

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