[Preparation and isolation on the rare ginsenoside derivatives with anti-cancer activity]

To prepare and isolate the rare ginsenoside derivatives of anti-cancer activity.

Acid-degradation products of ginsenosides were isolated and purified by various chromatographic techniques such as silica gel and so on; compounds were identified and elucidated by spectral and chemical methods.

Eleven compounds were obtained from the products of Acid-degradation.

Compound I, II are discoverd from the roots, stems, leaves, fruits and alabastrums of Panax quinquefolium L. for the first time. Compound IX of derivate of the aglycone of protopanoxadiol ginsenoside was discovered and reported, having the conspicuous anti-cancer activity for the first time from the fruits of Panax ginseng.