Related Experiment Video
Updated: Jun 20, 2026

Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure
Published on: September 4, 2010
Trace level haloacetic acids in drinking water by direct injection ion chromatography and single quadrupole mass
Johnson Mathew1, Rick McMillin, Jay Gandhi
1Houston Laboratory, Management Division, United States Environmental Protection Agency, 10625 Fallstone, Houston, TX 77099, USA.
Abstract:
Chlorine has been widely used to kill disease-causing microbes in drinking water. During the disinfection process, organic and inorganic material in source waters can combine with chlorine and certain other chemical disinfectants to form disinfection by-products. The kind of disinfectant used can produce different types and levels of disinfectant byproducts in the drinking water, such as trihalomethanes and haloacetic acids (5HAAs). Currently, USEPA Method 552 utilizes a methyl tert-butyl ether extraction and diazomethane derivatization of HAAs and phenolic disinfectant by-products, and a gas chromatograph equipped with a capillary column to perform the separation of methyl-haloacetates and anisoles. To detect, gas chromatography and electron capture detector are used. This article demonstrates a simple method using direct injection ion chromatography hyphenated with mass spectrometry for the analysis of 5HAAs.
More Related Videos
Related Concept Videos
Mass Spectrometry: Alkyl Halide Fragmentation
High-Performance Liquid Chromatography: Types of Detectors
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Chemical Ionization (CI) Mass Spectrometry
Mass Analyzers: Common Types
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

