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Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
Sylvain Bernard1, Daniel Defoy, Yves L Dory
1Département de Chimie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001 12e Avenue nord, Sherbrooke, Québec, Canada J1H 5N4.
Abstract:
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
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