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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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A modular rearrangement approach toward medicinally relevant phosphinic structures

Vassilis Rogakos1, Dimitris Georgiadis, Vincent Dive

  • 1Department of Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.

Organic Letters
|September 25, 2009
PubMed
Summary

A novel method efficiently creates medicinally important phosphinic compounds by coupling phosphorus-carbon and carbon-carbon bonds. This strategy utilizes a unique Ireland-Claisen rearrangement initiated by a phospha-Michael addition.

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