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Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom
N I Kiyatkin1, I E Dulubova, I A Chekhovskaya
1Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.
FEBS Letters
|September 17, 1990
Abstract:
cDNA encoding the putative alpha-latrotoxin precursor was isolated from spider venom glands cDNA library and sequenced. The cDNA contained the 4203 base-pair open reading frame corresponding to the 156,855-Da protein composed of 1401 amino acids. Computer analysis of the deduced primary structure revealed the presence of various internal imperfect repeats mainly in its central and C-terminal regions.