Related Experiment Video
Updated: Mar 28, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
Biological activity of a polypeptide modulator of TRPV1 receptor
I A Dyachenko1, Ya A Andreev2, Yu A Logashina3
1Pushchino Branch, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, 142292, Russia. dyachenko@bibch.ru.
Abstract:
This paper presents data on the activity of a new APHC2 polypeptide modulator of TRPV1 receptors, which was isolated from the sea anemone Heteractis crispa. It has been shown that APHC2 has an analgesic activity, does not impair normal motor activity, and does not change body temperature of experimental animals, which has a great practical value for design of potent analgesics of a new generation. Further study of the characteristics of binding of the polypeptide to the TRPV1 receptor may show approaches to the development of other antagonists of this receptor that do not influence the body temperature.
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Thermosensation
Mechanically-gated Ion Channels
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with...
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
GPCRs Regulate Adenylyl Cylase Activity

