Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study

In a case of Lewy body disease incidentally found at autopsy, numerous dense core vesicles 80--200 nm in diameter, were seen in the neuronal perikarya of the locus caeruleus. They were particularly numerous in the vicinity of the Lewy bodies. The change seems to occur at the early stage of Lewy body production and may represent an additional morphologic clue to abnormal catecholamine metabolism in Parkinson's disease.