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Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Related Experiment Video

Updated: Jun 20, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Reassembling biological machinery in vitro.

¹Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. hh2374@columbia.edu

Chemistry & Biology

|September 26, 2009

Summary

This summary is machine-generated.

Researchers immobilized key glycolytic enzymes, mimicking sperm flagella, to create efficient bio-energy converters. This work paves the way for novel bionanodevices that convert glucose into usable cellular energy (ATP).

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Last Updated: Jun 20, 2026

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Area of Science:

Biochemistry
Bioengineering
Nanotechnology

Background:

Mammalian sperm flagella utilize a specialized glycolytic system for energy production.
Controlled immobilization of enzymes is crucial for developing efficient biocatalytic systems.

Discussion:

Mukai et al. (2009) successfully immobilized two key enzymes from the glycolytic pathway.
This immobilization strategy is inspired by the energy conversion mechanisms in sperm flagella.

Key Insights:

Enzyme immobilization enables precise control over glycolytic reactions.
The study demonstrates a method for harnessing chemical energy from glucose.

Outlook:

Potential development of "power converters" for advanced bionanodevices.
Future applications include efficient transduction of chemical energy (glucose) to adenosine triphosphate (ATP).