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Cellular immune response of SIV-infected rhesus macaques
T P McGraw1, B R Vowels, M E Gershwin
1Department of Medical Pathology, University of California, Davis.
Journal of Medical Primatology
|January 1, 1990
Abstract:
Optimal conditions for the assessment of T cell proliferation and cytolytic T lymphocyte (CTL) responses specific for primate lentivirus were established. CTL and T cell proliferative responses were demonstrated as early as two weeks post-infection. Although the majority of CTL were CD8+, MHC class I-restricted, this study demonstrated CD4+, MHC class II-restricted CTL. Experiments also demonstrated that CTL were CD16 negative. Target cell generation could be blocked with CD4 mAb specific for the SIV binding site.