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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

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Published on: March 2, 2011

Testosterone reduces amygdala-orbitofrontal cortex coupling.

Guido van Wingen1, Claudia Mattern, Robbert Jan Verkes

  • 1Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands. guido.vanwingen@donders.ru.nl

Psychoneuroendocrinology
|September 29, 2009
PubMed
Summary
This summary is machine-generated.

Testosterone impacts emotional brain circuits by altering amygdala connectivity. This study found testosterone reduced orbitofrontal cortex coupling and increased thalamus coupling, potentially reducing regulatory control.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Testosterone influences affective behavior via emotion circuitry.
  • Neuroimaging shows testosterone increases amygdala neural activity.
  • Prefrontal cortex regulation of the amygdala is crucial for emotional processing.

Purpose of the Study:

  • To investigate exogenous testosterone's effects on amygdala interactions with other brain regions.
  • To explore testosterone's role in regulating amygdala functioning.
  • To examine testosterone's influence on functional coupling within the emotion circuitry.

Main Methods:

  • Randomized, placebo-controlled, crossover study design.
  • Single nasal testosterone dose administered to healthy middle-aged women.
  • Functional magnetic resonance imaging (fMRI) during an emotional face matching task.

Main Results:

  • Testosterone rapidly reduced amygdala functional coupling with the orbitofrontal cortex.
  • Testosterone enhanced amygdala coupling with the thalamus.
  • Testosterone reduced interhemispheric amygdala coupling, suggesting a role in sexual dimorphism.

Conclusions:

  • Testosterone may decrease regulatory control over the amygdala.
  • Testosterone may shift amygdala output from the orbitofrontal cortex to the thalamus.
  • Circulating testosterone may contribute to sex differences in interhemispheric amygdala coupling.