Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Confocal Fluorescence Microscopy

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Forensic 3D avatars - AI-assisted injury detection and interactive digital-twin visualization.

Forensic science, medicine, and pathology·2026

Same author

Teledermatological services at a Swiss university hospital - evaluation of patient benefits and economic impact .

The Journal of dermatological treatment·2025

Same author

Differentiating seborrheic keratosis from melanoma among lesions exhibiting blue-white veil: A retrospective study.

Journal of the American Academy of Dermatology·2024

Same author

Correlation of Genogroup I, Genotype 1 (GI.1) Norovirus Neutralizing Antibody Levels With GI.1 Histo-Blood Group Antigen-Blocking Antibody Levels.

The Journal of infectious diseases·2024

Same author

Automatized self-supervised learning for skin lesion screening.

Scientific reports·2024

Same author

International Skin Imaging Collaboration-Designated Diagnoses (ISIC-DX): Consensus terminology for lesion diagnostic labeling.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024

Same journal

Systemic therapy for advanced cutaneous squamous cell carcinoma.

Seminars in cutaneous medicine and surgery·2019

Same journal

Atypical Fibroxanthoma.

Seminars in cutaneous medicine and surgery·2019

Same journal

Introduction, High-Risk Skin Cancer.

Seminars in cutaneous medicine and surgery·2019

Same journal

Emerging technologies for health information in dermatology: opportunities and drawbacks of web-based searches, social media, mobile applications, and direct-to-consumer genetic testing in patient care.

Seminars in cutaneous medicine and surgery·2019

Same journal

MoleMapper: an application for crowdsourcing mole images to advance melanoma early-detection research.

Seminars in cutaneous medicine and surgery·2019

Same journal

Digital imaging applications and informatics in dermatology.

Seminars in cutaneous medicine and surgery·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Dermoscopy research--an update.

Ralph P Braun¹, H Rabinovitz, J E Tzu

¹Skin Cancer Diagnosis and Prevention Centre, Department of Dermatology, University Hospital, Zürich, Switzerland. Ralph.Braun@usc.ch

Seminars in Cutaneous Medicine and Surgery

|September 29, 2009

Summary

This summary is machine-generated.

Dermoscopy, a tool bridging clinical observation and pathology, significantly enhances diagnostic accuracy. This method offers new insights into skin morphology and tumor biology for researchers.

More Related Videos

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin

Published on: July 3, 2025

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

Related Experiment Videos

Last Updated: Jun 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin

In Vivo Confocal Microscopy: A Standard Operating Procedure for the Detection of Demodex Mites at the Eyelid Margin

Published on: July 3, 2025

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

Published on: November 11, 2025

Area of Science:

Dermatology
Medical Research
Oncology

Background:

Unaided visual inspection has limitations in diagnostic accuracy.
Dermoscopy serves as an in vivo link between clinical morphology and histopathology.
Previous meta-analyses confirm dermoscopy's benefit.

Purpose of the Study:

To provide an overview of dermoscopy as a research tool.
To highlight advancements in dermoscopy equipment and techniques.
To discuss the significance of vascular patterns in dermoscopy.

Main Methods:

Literature review and synthesis of evidence-based publications.
Analysis of dermoscopic findings in relation to clinical and histopathological data.
Exploration of new dermoscopic structures and their interpretation.

Main Results:

Dermoscopy improves diagnostic accuracy by up to 30% compared to visual inspection alone.
Dermoscopy provides novel insights into skin morphology and tumor biology.
New equipment and understanding of structures like blood vessels enhance its research utility.

Conclusions:

Dermoscopy is a valuable research tool in dermatology and oncology.
It bridges the gap between clinical observation and histopathology, offering deeper insights.
Continued research into dermoscopy will further advance understanding of skin diseases.