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Updated: Jun 20, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
Published on: December 8, 2010
Tissue oxygenation, perfusion, and position in patients with venous leg ulcers
D D Wipke-Tevis1, N A Stotts, D A Williams
1Sinclair School of Nursing, University of Missouri-Columbia, Columbia, MO 65211, USA.
Objectives:
The purpose of this study was to compare the partial pressure of transcutaneous tissue oxygen (TcPO2) in persons with venous ulcers in four positions with and without inspired oxygen.
Methods:
TcPO2 was evaluated two times, 4 weeks apart at a chest reference and three lower extremity sites.
Results:
Lower extremity resting TcPO2 levels were lower in patients with venous ulcers than in healthy adults. Minimal changes in TcPO2 occurred with position changes when subjects breathed room air. When arterial oxygen saturation was increased using inspired oxygen, TcPO2, used as an indicator of perfusion, was lower during leg elevation, sitting, and standing compared to lying supine (p < 0.05).
Conclusions:
Control of peripheral circulation and tissue oxygenation may be impaired in persons with venous ulcers. Leg elevation, sitting, and standing decreased wound perfusion and may not be beneficial to individuals with venous insufficiency and ulceration. Research is needed to explore relationships among tissue oxygenation, blood perfusion, compression, positioning, and venous ulcer healing.
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