Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world PD-L1 testing, fi rst-line therapy for advanced NSCLC, and fi rst-line pembrolizumab monotherapy utilization and outcomes for metastatic NSCLC in the Czech Republic.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2025

Same author

Cell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis.

Physiological research·2023

Same author

Effect of immunosuppressive therapy in inflammatory cardiomyopathy: data from The Czech Inflammatory Cardiomyopathy Immunosuppressive Trial.

Bratislavske lekarske listy·2021

Same author

Metformin therapy and risk of cancer in patients after heart transplantation.

Bratislavske lekarske listy·2021

Same author

Association between the heart rate early after heart transplantation and the long term clinical outcomes.

Bratislavske lekarske listy·2017

Same author

Autonomic cardiac regulation, blood pressure and cardiorespiratory fitness responses to different training doses over a 12 week group program in the elderly.

Archives of gerontology and geriatrics·2017

Same journal

Pharmacological profile of mepolizumab.

Vnitrni lekarstvi·2023

Same journal

Atypical form of Goodpasture's disease.

Vnitrni lekarstvi·2023

Same journal

Differentiated thyroid cancer - possible risks of treatment, suppressive therapy and adherence to current recommendations.

Vnitrni lekarstvi·2023

Same journal

Dyslipidemia - the known unknown.

Vnitrni lekarstvi·2023

Same journal

Internal comorbidities and complications of multiple sclerosis therapy - don't be caught off guard!

Vnitrni lekarstvi·2023

Same journal

Implications of highly suppressive treatment HIV infection.

Vnitrni lekarstvi·2023

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

A Modified Method for Heterotopic Mouse Heart Transplantion

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 23, 2014

[Heart transplantation].

P Hude¹, L Spinarová, J Krejcí

¹I. interní kardio-angiologická klinika Lékarské fakulty MU a FN u sv. Anny Brno. petr.hude@fnusa.cz

Vnitrni Lekarstvi

|September 30, 2009

Summary

This summary is machine-generated.

Heart transplantation is a complex treatment for end-stage heart failure, requiring careful timing and lifelong immunosuppression. Future care depends on new drugs and non-invasive rejection diagnosis.

More Related Videos

Murine Heterotopic Heart Transplant Technique

Murine Heterotopic Heart Transplant Technique

Published on: July 8, 2014

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

Related Experiment Videos

Last Updated: Jun 20, 2026

A Modified Method for Heterotopic Mouse Heart Transplantion

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 23, 2014

Murine Heterotopic Heart Transplant Technique

Murine Heterotopic Heart Transplant Technique

Published on: July 8, 2014

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

A Modified Cuff Technique for Mouse Cervical Heterotopic Heart Transplantation Model

Published on: February 7, 2022

Area of Science:

Cardiology
Transplantation Medicine
Immunology

Background:

The first human heart transplantation occurred in 1967, with widespread clinical application emerging in the 1980s.
Heart transplantation is a critical treatment for end-stage heart failure, but faces challenges due to limited donor organs and potential complications.
Post-transplantation management involves lifelong immunosuppressive therapy and careful monitoring for drug interactions.

Purpose of the Study:

To review the evolution and current status of heart transplantation.
To highlight the complexities in patient selection and timing of heart transplantation.
To discuss the challenges and future directions in managing heart transplant recipients.

Main Methods:

Literature review of heart transplantation history, surgical advancements, and immunosuppressive strategies.
Analysis of post-transplantation complications and management protocols.
Discussion of current therapeutic approaches and future research needs.

Main Results:

Heart transplantation has evolved from an experimental procedure to an established therapy for end-stage heart failure.
Optimal timing and patient selection remain crucial for successful outcomes.
Immunosuppression management is complex, requiring vigilance for drug interactions and adverse effects.

Conclusions:

Despite advancements, heart transplantation involves significant challenges, including organ availability and post-operative complications.
Long-term success hinges on meticulous pharmacological management and collaborative care between transplant teams and cardiologists.
Future advancements require novel immunosuppressive agents with fewer side effects and non-invasive methods for diagnosing graft rejection.