Related Experiment Video
Updated: Feb 27, 2026
A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
Association between the heart rate early after heart transplantation and the long term clinical outcomes
Insights
A higher early heart rate after heart transplantation is linked to worse survival outcomes. Lowering heart rate in heart transplant recipients may improve long-term survival.
Area of Science:
- Cardiology
- Transplantation Medicine
- Clinical Research
Background:
- A lower heart rate is associated with improved survival in general patient populations.
- The ideal heart rate for heart transplant recipients remains undetermined.
- Early post-transplant heart rate is a potential prognostic factor.
Purpose of the Study:
- To investigate the association between early heart rate and survival after heart transplantation.
- To determine if an elevated early heart rate impacts long-term outcomes in heart transplant patients.
Main Methods:
- Retrospective analysis of 330 heart transplant patients (1994-2014).
- 24-hour heart rate monitoring conducted one month post-transplantation.
- Patients categorized into two groups: average heart rate <90 bpm (Group A) and ≥90 bpm (Group B).
Main Results:
- No significant differences in baseline characteristics between groups.
- 10-year survival rates were 66% for Group A and 50% for Group B (p=0.001).
- Higher early heart rate was significantly associated with poorer survival.
Conclusions:
- Elevated early heart rate post-transplantation is a significant predictor of reduced survival.
- Targeting a lower heart rate in the early post-transplant period may enhance patient outcomes.
- Further research is warranted to establish optimal heart rate targets for heart transplant recipients.
Background:
A strong correlation between a lower heart rate and survival has been demonstrated in various patient populations. The optimal heart rate for heart transplant patients is still unknown. The aim of our study was to evaluate the association between an early heart rate and survival after heart transplantation.
Material And Methods:
We retrospectively analysed a group of 330 patients, who underwent heart transplantation in our institution from 1994 to 2014 and complete datasets, including 24-hour heart rate monitoring one month after the heart transplantation. Patients were divided in 2 groups: Group A (n = 278) with the average 24-hour heart rate <90 bpm, and Group B (n = 52) with ≥ 90 bpm.
Results:
The average period of monitoring was 7.5 ± 5.3 years. No differences in baseline characteristics were observed in both groups of recipients and respective donors. One-year survival in groups A and B was 92 % and 81 %, respectively; 5-year survival was 79 % and 60 %, respectively; and 10-year survival was 66 % and 50 %, respectively (p = 0.001).
Conclusion:
Increased heart rate in the early post-transplant period was significantly associated with a poorer survival rate in patients after heart transplantation (Tab. 2, Fig. 1, Ref. 25).
More Related Videos
08:49Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
Published on: August 2, 2024
12:40A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
Published on: September 28, 2022
Related Concept Videos
01:30Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
01:26Heart Failure III: Clinical Manifestations
01:29Heart Failure II: Pathophysiology
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...