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Related Concept Videos

Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

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Related Experiment Video

Updated: Jun 20, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Pancreatitis and systemic lupus erythematosus.

J Lariño Noia1, F Macías García, S Seijo Ríos

  • 1Gastroenterology Department, University Hospital of Santiago, Santiago de Compostela, A Coruña, Spain. jlarnoi1976@fienad.com

Revista Espanola De Enfermedades Digestivas
|September 30, 2009
PubMed
Summary

Systemic lupus erythematosus (SLE) patients commonly experience gastrointestinal issues. Pancreatic diseases, particularly acute pancreatitis, are less frequent but linked to SLE, with chronic pancreatitis being rare.

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Last Updated: Jun 20, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Published on: June 28, 2021

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Rheumatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Gastrointestinal symptoms, especially abdominal pain, are prevalent in Systemic Lupus Erythematosus (SLE).
  • Pancreatic diseases occur in less than 5% of SLE patients, primarily as acute pancreatitis.
  • Chronic pancreatitis association with SLE is exceptionally rare, with limited published cases.

Observation:

  • This study details three cases of SLE-associated pancreatitis.
  • Analysis includes disease onset, etiological factors, and clinical progression.
  • Literature review on pathophysiological mechanisms and corticosteroid role is incorporated.

Findings:

  • Acute pancreatitis is the predominant pancreatic manifestation in SLE patients.
  • Chronic pancreatitis is an uncommon but documented association with SLE.
  • Corticosteroid use may play a role in SLE-associated pancreatic disease.

Implications:

  • Highlights the importance of considering pancreatic complications in SLE patients with abdominal pain.
  • Informs clinical management by detailing etiological factors and progression.
  • Contributes to understanding the pathophysiology of SLE-related pancreatic conditions.