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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Pancreatitis and systemic lupus erythematosus.
J Lariño Noia1, F Macías García, S Seijo Ríos
1Gastroenterology Department, University Hospital of Santiago, Santiago de Compostela, A Coruña, Spain. jlarnoi1976@fienad.com
Revista Espanola De Enfermedades Digestivas
|September 30, 2009
Summary
Systemic lupus erythematosus (SLE) patients commonly experience gastrointestinal issues. Pancreatic diseases, particularly acute pancreatitis, are less frequent but linked to SLE, with chronic pancreatitis being rare.
Area of Science:
- Rheumatology
- Gastroenterology
- Internal Medicine
Background:
- Gastrointestinal symptoms, especially abdominal pain, are prevalent in Systemic Lupus Erythematosus (SLE).
- Pancreatic diseases occur in less than 5% of SLE patients, primarily as acute pancreatitis.
- Chronic pancreatitis association with SLE is exceptionally rare, with limited published cases.
Observation:
- This study details three cases of SLE-associated pancreatitis.
- Analysis includes disease onset, etiological factors, and clinical progression.
- Literature review on pathophysiological mechanisms and corticosteroid role is incorporated.
Findings:
- Acute pancreatitis is the predominant pancreatic manifestation in SLE patients.
- Chronic pancreatitis is an uncommon but documented association with SLE.
- Corticosteroid use may play a role in SLE-associated pancreatic disease.
Implications:
- Highlights the importance of considering pancreatic complications in SLE patients with abdominal pain.
- Informs clinical management by detailing etiological factors and progression.
- Contributes to understanding the pathophysiology of SLE-related pancreatic conditions.
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