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Is there a relationship between Helicobacter pylori infection and erosive reflux disease in children?

Halil Haldun Emiroglu1, Semra Sokucu, Ozlem Durmaz Suoglu

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey. haldunemiroglu@hotmail.com

Acta Paediatrica (Oslo, Norway : 1992)
|September 30, 2009
PubMed

Insights

This study found no significant link between Helicobacter pylori infection and erosive reflux disease in children. Helicobacter pylori did not affect the severity of oesophagitis in pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Gastroesophageal reflux disease (GERD) is a common condition in children.
  • Helicobacter pylori (H. pylori) infection is prevalent globally.
  • The relationship between H. pylori and GERD, particularly erosive esophagitis, in pediatric populations requires further investigation.

Purpose of the Study:

  • To investigate the association between H. pylori infection and erosive reflux disease in children.
  • To determine if H. pylori infection influences the severity of esophagitis in pediatric patients.

Main Methods:

  • Retrospective analysis of 206 children undergoing upper endoscopy.
  • H. pylori infection status determined through testing.
  • Gastroesophageal reflux disease diagnosed based on endoscopic and histopathological findings, categorizing patients into erosive and non-erosive groups.

Main Results:

  • Prevalence of H. pylori infection was similar in children with and without GERD (31.3% vs. 36.7%).
  • Erosive esophagitis prevalence was not significantly different between H. pylori-infected and H. pylori-negative children (23.8% vs. 41.3%).
  • H. pylori infection did not correlate with the severity of esophagitis.

Conclusions:

  • No significant negative association was found between H. pylori infection and erosive esophagitis in children.
  • H. pylori infection does not appear to influence the severity of esophagitis in the studied pediatric cohort.
Abstract

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