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Updated: Jun 20, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Urinary uric acid and antioxidant capacity in children and adults with Down syndrome
Carlos Campos1, Rodrigo Guzmán, Encarnación López-Fernández
1Departamento de Medicina Celular y Molecular, Centro de Investigaciones Biológicas, CSIC, C/ Ramiro de Maeztu, 9. E-28040 Madrid, Spain. ccampos@cib.csic.es
Objectives:
To evaluate the urinary levels of uric acid (UA) and total antioxidant capacity (TAC) with and without UA relative contribution (TAC(-UA)) in children and adults with Down syndrome (DS) and to prove the clinical use of TAC.
Design And Methods:
Urine samples were obtained from 32 individuals with DS and 29 controls. Two age groups were established (children and adults). Spectrophotometric methods were used for biochemical determinations.
Results:
Children with DS had significantly higher UA/Cr and TAC/Cr levels than controls, whereas levels of TAC(-UA)/Cr were lower in adults with DS than in controls (P<0.05 for all). In DS, levels of UA/Cr, TAC/Cr and TAC(-UA)/Cr were higher in children than in adults (P<0.05 for all). Positive correlations between UA/Cr and TAC/Cr were found for all groups studied. Negative correlations with age were found for UA/Cr and TAC/Cr in children of both groups.
Conclusions:
Our results proved that TAC is decreased in adults with DS. Besides, TAC(-UA) seems to provide more reliable information about the antioxidant status, at least in DS.
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