Related Experiment Video
Updated: Jun 20, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
TransmiR: a transcription factor-microRNA regulation database.
Juan Wang1, Ming Lu, Chengxiang Qiu
1Department of Biomedical Informatics, Peking University School of Basic Medical Sciences and MOE Key Laboratory of Molecular Cardiology, Peking University, Beijing 100191, China.
Nucleic Acids Research
|September 30, 2009
Summary
This study compiles 243 experimentally validated transcription factor (TF)-microRNA (miRNA) regulatory relationships. The TransmiR database aids research into TF-miRNA roles in diseases and gene regulation.
Area of Science:
- Molecular Biology
- Genetics
- Bioinformatics
Background:
- MicroRNAs (miRNAs) are crucial posttranscriptional gene regulators.
- Transcription factors (TFs) control gene transcription, including miRNA genes.
- Dysregulated TF-miRNA interactions are linked to diseases.
Purpose of the Study:
- To establish a comprehensive database of TF-miRNA regulatory relationships.
- To facilitate understanding of TF-miRNA regulatory mechanisms.
- To explore the role of TF-miRNA dysregulation in disease.
Main Methods:
- Manual literature survey of ~5000 reports.
- Identification and curation of experimentally supported TF-miRNA interactions.
- Database construction using collected data.
Main Results:
- Identified 243 TF-miRNA regulatory relationships from 86 publications.
- Built the TransmiR database containing 82 TFs and 100 miRNAs.
- Included annotations for organism, tumor involvement, miRNA function, and disease association.
Conclusions:
- The TransmiR database provides a valuable resource for TF-miRNA research.
- Facilitates retrieval of regulatory pairs via a user-friendly interface.
- Supports studies on gene regulation and disease mechanisms involving TFs and miRNAs.
Related Concept Videos
02:16Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
02:16Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
01:22MicroRNAs
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
02:23Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...