Double phase transfer of gold nanorods for surface functionalization and entrapment into PEG-based nanocarriers

A novel double phase transfer process was achieved to develop PEG-based targetable nanostructures containing gold nanorods: in the first phase transfer, lipophilic free-CTAB gold nanorods have been obtained, by a straightforward one-step ligand exchange reaction in hydro-alcoholic mixture with thiols, then a second phase transfer was performed to entrap them into PEG-based polymeric nanoparticles.