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ArteFill permanent injectable for soft tissue augmentation: I. Mechanism of action and injection techniques
Gottfried Lemperle1, Terry R Knapp, Neil S Sadick
1Division of Plastic Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. glemperle@aol.com
Aesthetic Plastic Surgery
|September 30, 2009
Summary
ArteFill is a permanent injectable wrinkle filler using polymethylmethacrylate (PMMA) microspheres. It corrects nasolabial folds by stimulating the patient's own connective tissue for long-lasting results.
Area of Science:
- Dermatology
- Plastic Surgery
- Biomaterials Science
Background:
- ArteFill, approved in 2006, is the first permanent injectable wrinkle filler.
- It is a third-generation filler, succeeding Artecoll.
- Utilized for nasolabial fold correction since February 2007 in over 15,000 patients.
Purpose of the Study:
- To evaluate the composition and mechanism of ArteFill for wrinkle correction.
- To detail the histological outcomes and long-term efficacy of ArteFill injections.
Main Methods:
- ArteFill composition: 20% polymethylmethacrylate (PMMA) microspheres (30-50 microm) in 80% bovine collagen (3.5%) with lidocaine (0.3%).
- Injection technique: Subdermal tunneling to create a supportive strand.
- Histological analysis to determine tissue composition post-injection.
Main Results:
- Collagen carrier absorbed within 1 month, replaced by patient's connective tissue within 3 months.
- Long-term correction comprises 80% patient's connective tissue and 20% PMMA microspheres.
- No serious side effects reported to the FDA MAUDE database.
Conclusions:
- ArteFill provides permanent wrinkle correction through tissue regeneration.
- The PMMA microspheres act as a scaffold for new connective tissue growth.
- Offers a durable solution for nasolabial fold correction with a favorable safety profile.
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