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Prospective Single-Site Open-label Study Assessing Safety and Efficacy of Poly-L-Lactic Acid for Temple Volume Loss
Journal of Drugs in Dermatology : JDD
|January 6, 2026
Summary
Injectable Poly-l-lactic acid (PLLA) effectively restored temple volume and improved facial shape. This biostimulatory filler demonstrated safety and efficacy for treating age-related facial volume loss.
Area of Science:
- Aesthetic Medicine
- Dermatology
- Regenerative Medicine
Background:
- Poly-l-lactic acid (PLLA) is an injectable biostimulatory agent.
- It is utilized for replenishing lost facial volume, particularly due to aging.
Purpose of the Study:
- To assess the safety and effectiveness of PLLA injections in the temples.
- Dual plane injection techniques were employed to address temporal volume loss.
Main Methods:
- Standardized photographic and live assessments were conducted.
- Ultrasound imaging was used to evaluate injection planes and vascularity.
- Evaluations occurred at 4, 8, 12, and 16 weeks post-treatment.
Main Results:
- Significant increases in temporal volume and skin elasticity were observed by 8 weeks.
- PLLA treatment was well-tolerated, with minor, self-resolving side effects.
- Ultrasound confirmed safe injection planes, free from vascular structures.
Conclusions:
- Repeated PLLA injections improved overall facial shape, especially the mid and upper face.
- Temple hollowness and facial laxity showed improvement over time.
- No significant safety concerns or sequelae were reported.
