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Updated: Jun 20, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules
Nicolas Anton1, Patrick Saulnier, Cédric Gaillard
1CNRS 7199, Conception et Application de Molécules Bioactives, Pharmacie Biogalénique, Université de Strasbourg, Faculté de Pharmacie, BP 60024 F-67401 Illkirch Cedex, France. nicolas.anton@pharma.u-strasbg.fr
Abstract:
This paper presents the original method of producing aqueous-core lipid nanocapsule, able to encapsulate both hydrophilic and lipophilic species with relevant yields. The scope offered by the integration of both hydrophilic and lipophilic molecules within the same colloidal objects make this method a prime candidate for the numerous anticancer therapies for which chemotherapy frequently requires the association of several molecules. The proof of concept study is proposed here (i) describing in detail the formulation of such objects and their characterization (TEM, cryo-TEM, soft particle analysis), (ii) showing the encapsulation of hydrophilic species alone, using examples of very different molecular weights, such as a dye (methylene blue) and a protein (BSA-isothycianate fluorecein labeled), and (iii) showing the simultaneous encapsulation of hydrophilic (methylene blue) and lipophilic (also a dye, red Sudan III) species.
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