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Related Concept Videos

Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...

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Related Experiment Video

Updated: Jun 20, 2026

Glass-Based Devices to Generate Drops and Emulsions
08:45

Glass-Based Devices to Generate Drops and Emulsions

Published on: April 5, 2022

Electrospray technique for solid lipid-based particle production.

M Trotta1, R Cavalli, C Trotta

  • 1Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Torino, Italy. michele.trotta@unito.it

Drug Development and Industrial Pharmacy
|October 1, 2009
PubMed
Summary
This summary is machine-generated.

Electrospraying efficiently produces sub-micron, drug-loaded lipid nanoparticles. This method offers a single-step approach for creating monodisperse particles for controlled drug delivery.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Lipid micro- and nanoparticles are crucial for controlled drug release formulations.
  • Novel preparation techniques for these particles are gaining significant research interest.

Purpose of the Study:

  • To produce solid lipid-based micro-nanospheres using electrohydrodynamic atomization (electrospraying).
  • To assess the suitability of electrospraying for preparing drug-loaded lipid particles.

Main Methods:

  • Electrospraying was employed to generate micro-nanospheres.
  • Stearic acid and ethylcellulose (4.5:0.5 w/w) were used as lipid components.
  • Tamoxifen was utilized as a model drug for encapsulation studies.

Main Results:

  • Spherical, narrowly dispersed particles (<1 µm) were successfully produced, suitable for cellular internalization.
  • High entrapment efficiency was achieved for the model drug (Tamoxifen).
  • In vitro drug release studies demonstrated a prolonged release profile after an initial burst effect.

Conclusions:

  • Electrospraying is a viable single-step method for producing monodisperse, lipid-based micro- and nanoparticles in powder form.
  • This technique shows promise for advanced drug delivery applications.
  • The prepared particles are suitable for controlled release of encapsulated therapeutics.