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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
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Hormones That Influence Osteoblasts and/or Maintain the Matrix
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

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Synthesis and Functions of Calcitonin00:51

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Related Experiment Video

Updated: Jun 20, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Significance of elevated parathyroid hormone after parathyroidectomy.

Diane M Biskobing1

  • 1Department of Medicine, Division of Endocrinology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA. dbiskobing@mcvh-vcu.edu

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|October 1, 2009
PubMed
Summary

Elevated parathyroid hormone (PTH) is common after surgery for primary hyperparathyroidism, affecting up to 62% of patients. This elevation, even with normal calcium levels, does not indicate surgical failure, but its cause remains unclear.

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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Last Updated: Jun 20, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

  • Endocrinology
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism is a condition characterized by excessive parathyroid hormone (PTH) secretion.
  • Parathyroidectomy is the surgical removal of one or more parathyroid glands and is the definitive treatment for primary hyperparathyroidism.

Purpose of the Study:

  • To determine the prevalence of elevated parathyroid hormone (PTH) after parathyroidectomy for primary hyperparathyroidism.
  • To explore potential mechanisms underlying postoperative PTH elevation.

Main Methods:

  • A comprehensive literature search was conducted on Medline for English-language studies published between 1990 and 2009.
  • Included studies focused on parathyroidectomy for primary hyperparathyroidism, excluding those with secondary or tertiary hyperparathyroidism.

Main Results:

  • Postoperative elevated PTH concentrations were reported in 9% to 62% of patients with normal serum calcium levels within 1 week to 5 years after surgery.
  • Preoperative factors associated with elevated PTH include lower vitamin D levels, higher bone turnover markers, and higher PTH levels.
  • Potential mechanisms include vitamin D deficiency, hungry bone syndrome, and PTH resistance; however, no randomized trials support postoperative supplementation.

Conclusions:

  • Elevated parathyroid hormone (PTH) is a frequent occurrence following parathyroidectomy for primary hyperparathyroidism.
  • The precise mechanisms driving this postoperative PTH elevation in normocalcemic patients require further investigation.