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Muscle giants: molecular scaffolds in sarcomerogenesis

Aikaterini Kontrogianni-Konstantopoulos1, Maegen A Ackermann, Amber L Bowman

  • 1Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. akons001@umaryland.edu

Physiological Reviews
|October 1, 2009
PubMed
Summary

Giant muscle proteins titin, nebulin, and obscurin are crucial for sarcomere assembly. While they act as scaffolds, their roles as molecular guides in muscle development remain debated.

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