Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The choice of μ-vinyliminium ligand substituents is key to optimize the antiproliferative activity of related diiron complexes.

Metallomics : integrated biometal science·2022

Same author

Additive Manufacturing of Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate)/Poly(D,L-lactide-<i>co</i>-glycolide) Biphasic Scaffolds for Bone Tissue Regeneration.

International journal of molecular sciences·2022

Same author

Polymeric Hydrogels for In Vitro 3D Ovarian Cancer Modeling.

International journal of molecular sciences·2022

Same author

Development and Characterization of Highly Stable Silver NanoParticles as Novel Potential Antimicrobial Agents for Wound Healing Hydrogels.

International journal of molecular sciences·2022

Same author

Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery.

Nanomaterials (Basel, Switzerland)·2022

Same author

Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization.

International journal of molecular sciences·2022

Same journal

The effect of glycyrrhetinic acid on pharmacokinetics of cortisone and its metabolite cortisol in rats.

Journal of biomedicine & biotechnology·2012

Same journal

Insights and hopes in umbilical cord blood stem cell transplantations.

Journal of biomedicine & biotechnology·2012

Same journal

Three-dimensional visualization with large data sets: a simulation of spreading cortical depression in human brain.

Journal of biomedicine & biotechnology·2012

Same journal

Bioconversion of sugarcane biomass into ethanol: an overview about composition, pretreatment methods, detoxification of hydrolysates, enzymatic saccharification, and ethanol fermentation.

Journal of biomedicine & biotechnology·2012

Same journal

Trends in tissue engineering for blood vessels.

Journal of biomedicine & biotechnology·2012

Same journal

Salinomycin as a drug for targeting human cancer stem cells.

Journal of biomedicine & biotechnology·2012

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

Poly(hydroxyalkanoates)-based polymeric nanoparticles for drug delivery.

Cesare Errico¹, Cristina Bartoli, Federica Chiellini

¹Laboratory of Bioactive Polymeric Materials for Biomedical & Environmental Applications, UdR-INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126 Pisa, Italy.

Journal of Biomedicine & Biotechnology

|October 1, 2009

Summary

This summary is machine-generated.

Poly (hydroxyalkanoates) (PHAs), specifically Poly(3-hydroxybutyrate) (PHB) nanoparticles, were prepared using a novel dialysis method. These biodegradable nanoparticles show promise for biomedical applications due to their small size and excellent biocompatibility.

More Related Videos

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Polymer science
Materials science
Biomedical engineering

Background:

Poly (hydroxyalkanoates) (PHAs) are gaining interest for biomedical and environmental uses due to biodegradability and biocompatibility.
Poly(3-hydroxybutyrate) (PHB) is a type of PHA with potential for nanoparticle development.
Existing methods for nanoparticle preparation have limitations in terms of size and homogeneity.

Purpose of the Study:

To develop a novel dialysis method for preparing Poly(3-hydroxybutyrate) (PHB) nanoparticles.
To investigate the effect of processing conditions on nanoparticle characteristics.
To evaluate the morphology, drug encapsulation, and size of the prepared nanoparticles.

Main Methods:

Nanoparticles were prepared using the dialysis method, a technique not previously reported for PHB.
Processing conditions were systematically varied to optimize nanoparticle formation.
Morphology, drug encapsulation efficiency, and particle size distribution were analyzed.

Main Results:

The dialysis method yielded PHB nanoparticles with a relatively small diameter and homogeneous size distribution.
This method offers advantages over techniques like solvent evaporation, which produce microscale particles.
PHB and its nanoparticles demonstrated excellent cytocompatibility in biocompatibility studies.

Conclusions:

The developed dialysis method is effective for producing small, uniform PHB nanoparticles.
PHB nanoparticles are suitable for biomedical applications owing to their favorable characteristics and biocompatibility.
This research provides a theoretical understanding of colloidal formation relevant to PHA nanoparticle synthesis.