Related Experiment Video
Updated: Jun 19, 2026

Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
Published on: October 30, 2018
Bringing DNA vaccines closer to commercial use
Joana A Carvalho1, Duarte M F Prazeres, Gabriel A Monteiro
1Instituto Superior Técnico, Avenue Rovisco Pais 1, 1049-001 Lisbon, Portugal.
Abstract:
Progress in the application of DNA vaccines as an immunization protocol is evident from the increasing number of such vaccines under evaluation in clinical trials and by the recent approval of several DNA vaccine products for veterinary applications. DNA vaccine technology offers important therapeutic and commercial advantages compared with conventional approaches, including the opportunity to target pathogens characterized by significant genetic diversity using a safe immunization platform, and the ability to use a simple, rapid and well-characterized production method. However, further optimization of DNA vaccine technology through the use of improved constructs, delivery systems and immunization protocols is necessary to clinically achieve the promising results that have been demonstrated in preclinical models.
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