Malignant melanoma derived from cerebriform intradermal naevus

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Cutis verticis gyrata (CVG) is a rare condition characterized by scalp convolutions.
• Cerebriform intradermal naevus (CIN) is a type of benign skin growth.
• Malignant melanoma (MM) is a serious form of skin cancer.

Observation:

• A 66-year-old man with congenital CVG developed a nodule within an extensive CIN.
• Histopathological examination confirmed the nodule as malignant melanoma (MM) arising from the CIN.
• No lymph node or distant metastasis was detected.

Findings:

• This case represents the third reported instance of MM developing from CIN.
• The estimated incidence of MM from CIN is 4.5%, comparable to giant pigmented naevi.
• MM arising within CIN is a rare but significant clinical event.

Implications:

• Pathological examination of CVG is recommended to identify underlying CIN.
• Patients diagnosed with CIN require long-term clinical surveillance for early MM detection.
• Understanding the malignant potential of CIN is vital for patient management and prognosis.