Related Experiment Video
Updated: Jun 19, 2026
06:25
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Simian parvoviruses: biology and implications for research
1Charles River Laboratories, Wilmington, MA, USA. meredith.simon@crl.com
Comparative Medicine
|October 2, 2009
Summary
Simian parvoviruses (SPVs), related to human B19, commonly infect macaques but are usually silent. Disease occurs mainly in immunosuppressed macaques, posing risks in research settings.
Area of Science:
- Virology
- Primate Immunology
- Infectious Diseases
Background:
- Simian parvoviruses (SPVs) belong to the genus Erythrovirus, closely related to human parvovirus B19.
- SPVs are prevalent in cynomolgus, rhesus, and pigtailed macaques, targeting erythroid precursor cells.
Purpose of the Study:
- To review the characteristics of simian parvoviruses (SPVs).
- To highlight the association of SPV disease with immunosuppression in macaques.
- To underscore the relevance of SPV in research involving macaques.
Main Methods:
- Literature review of simian parvovirus (SPV) infections in macaques.
- Analysis of factors contributing to SPV-associated disease.
- Evaluation of SPV prevalence and clinical manifestations.
Main Results:
- SPV infections are common in macaques but typically asymptomatic.
- Disease manifestation is linked to immunosuppression from retroviral infections, surgery, or drug toxicity.
- SPV-positive macaques present risks in research settings.
Conclusions:
- Simian parvoviruses are widespread in macaque populations.
- Immunosuppression is a critical factor for SPV disease development.
- Researchers must consider SPV status in macaques, especially those undergoing immunosuppressive treatments or protocols.
More Related Videos
13:13Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques
Published on: September 25, 2018
08:40Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
Related Concept Videos
00:36Viral Mutations
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
01:26Size and Structure of Viral Genomes
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
00:57Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
02:33Retroviruses
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...