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Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...

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Related Experiment Video

Updated: Jun 19, 2026

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice
04:00

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice

Published on: September 13, 2024

Scents and nonsense: olfactory dysfunction in schizophrenia.

Bruce I Turetsky1, Chang-Gyu Hahn, Karin Borgmann-Winter

  • 1Department of Psychiatry, 10th Floor,Gates Building,University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. turetsky@upenn.edu

Schizophrenia Bulletin
|October 2, 2009
PubMed
Summary

Olfactory dysfunction is a sensitive indicator of schizophrenia pathology, potentially serving as an early warning sign. Research shows structural and functional abnormalities in the olfactory system, from the brain to peripheral elements, linked to schizophrenia.

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Simple and Computer-assisted Olfactory Testing for Mice
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Simple and Computer-assisted Olfactory Testing for Mice

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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Related Experiment Videos

Last Updated: Jun 19, 2026

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice
04:00

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice

Published on: September 13, 2024

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Area of Science:

  • Neuroscience
  • Psychiatry
  • Sensory Systems Biology

Background:

  • Olfaction is closely linked to frontal and temporal brain regions affected in schizophrenia.
  • These brain regions are crucial for affective and mnemonic functions.
  • Olfactory probes can assess neural substrates of cognitive and emotional disturbances in schizophrenia.

Purpose of the Study:

  • Review evidence for primary olfactory sensory disturbance in schizophrenia.
  • Explore the olfactory system's vulnerability and potential as an early indicator of schizophrenia.
  • Investigate structural, functional, cellular, and molecular abnormalities in the olfactory system.

Main Methods:

  • Review of existing scientific literature and data.
  • Analysis of structural and functional abnormalities from the brain's cortex to peripheral olfactory elements.
  • Examination of cellular and molecular changes, including potential epigenetic regulation.

Main Results:

  • Convergent data support primary olfactory sensory disturbance in schizophrenia.
  • Abnormalities are observed throughout the olfactory system, reflecting neurodevelopmental etiology.
  • Evidence suggests decreased/faulty innervation and intracellular signaling dysregulation.

Conclusions:

  • Olfactory dysfunction is a sensitive indicator and potential early warning sign for schizophrenia.
  • The peripheral olfactory system, accessible via nasal biopsy, offers a unique window into schizophrenia pathophysiology.
  • Studying olfactory system abnormalities can clarify brain mechanisms and identify biomarkers for schizophrenia.