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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Impact of hypothermia in the rural, pediatric trauma patient
Brett H Waibel1, Chris A Durham, Mark A Newell
1Department of Surgery, Division of Trauma and Surgical Critical Care, The Brody School of Medicine, East Carolina University, Greenville, NC, USA. Brett.Waibel@pcmh.com
Insights
Hypothermia in pediatric trauma patients increases mortality risk and bleeding issues but lowers pneumonia odds. Length of stay was not significantly impacted after controlling for confounders.
Area of Science:
- Pediatric Trauma Care
- Critical Care Medicine
- Hypothermia Research
Background:
- Hypothermia is a known mortality predictor in adult trauma.
- The impact of hypothermia on pediatric trauma outcomes remains understudied.
Purpose of the Study:
- To investigate hypothermia as a factor in pediatric trauma mortality.
- To assess hypothermia's association with complications and hospital stay among pediatric trauma survivors.
Main Methods:
- Retrospective analysis of a prospectively collected trauma registry (5-year period).
- Inclusion of 1,629 pediatric patients admitted with traumatic injuries.
- Multivariate regression models to analyze associations.
Main Results:
- 11.1% of pediatric trauma patients were hypothermic on admission.
- Hypothermia significantly increased mortality odds (AOR 2.41).
- Hypothermia was associated with increased odds of bleeding diathesis and decreased odds of pneumonia.
Conclusions:
- Hypothermia is a prevalent issue in pediatric trauma admissions.
- Hypothermia is linked to higher mortality and bleeding complications in pediatric trauma.
- No significant association found between hypothermia and hospital/ICU/ventilator days in survivors after adjustments.
Objective:
Hypothermia is an independent predictor of mortality in adult trauma studies. However, the impact of hypothermia on the pediatric trauma population has not been described. The purpose of this study is to evaluate hypothermia as a cofactor to mortality, complications, and among survivors, hospital length of stay parameters in the pediatric trauma population.
Design:
Retrospective review of a prospectively collected database (National Trauma Registry of the American College of Surgeons) over a 5-yr period (July 2002 to June 2007).
Setting:
A rural, level I trauma center.
Patients:
One thousand six hundred twenty-nine pediatric patients admitted with a traumatic injury.
Interventions:
None.
Measurements And Main Results:
Multivariate regression models were used to evaluate the association of hypothermia with mortality, infectious complications, organ dysfunction, and among survivors, hospital length of stay parameters. Of 1,629 pediatric trauma patients admitted, 182 (11.1%) patients were hypothermic (temperature below 36 degrees C) on admission. Hypothermia had an adjusted odds ratio (AOR) of 2.41 (95% confidence interval [CI], 1.12-5.22, p = .025) for mortality. After controlling for covariates, hypothermia had associations with developing pneumonia (AOR, 0.185, 95% CI, 0.040-0.853; p = .031) and a bleeding diathesis (AOR, 3.14, 95% CI, 1.04-9.44; p = .042). The median days in the hospital, intensive care unit (ICU), and ventilator were longer in the hypothermic cohort; however, after controlling for covariates, hypothermia was not associated with differences in hospital days, ICU days, or ventilator days.
Conclusions:
Hypothermia is a common problem at admission among pediatric trauma patients. Hypothermia is associated with an increase in the odds of death and the development of a bleeding diathesis, while having decreased odds for developing pneumonia. While the length of stay indicators were longer in the hypothermic cohort among survivors, no significant association was noted with hypothermia for hospital, ICU, or ventilator days after controlling for confounders.
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