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Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

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Updated: Jun 19, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

[Psoriasis--clinical picture and current therapy].

Kaweh Shakery¹, Kristian Reich

¹SCIderm GmbH, Esplanade 6, 20354 Hamburg und Dermatologikum Hamburg, Drehbahn 1-3, 20354 Hamburg. kaweh.shakery@sciderm.com

Medizinische Monatsschrift Fur Pharmazeuten

|October 3, 2009

Summary

This review covers psoriasis epidemiology, genetics, and pathogenesis, detailing clinical presentations, associated conditions, and treatment options including topical, phototherapy, and systemic therapies like biologics.

Area of Science:

Dermatology
Immunology
Genetics

Context:

Psoriasis is a chronic inflammatory skin condition with significant genetic and pathogenic components.
Understanding its epidemiology and associated diseases is crucial for comprehensive patient care.

Purpose:

To provide an updated overview of psoriasis epidemiology, genetics, and pathogenesis.
To describe clinical manifestations, comorbidities, and current treatment strategies for continuing education.

Summary:

This review synthesizes current knowledge on psoriasis, encompassing its epidemiological data, genetic underpinnings, and pathogenic mechanisms.
It details the diverse clinical spectrum and severity grades of psoriasis, alongside significant associated diseases.
Therapeutic approaches discussed include topical treatments, phototherapy, and systemic therapies, notably modern biological agents.

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Last Updated: Jun 19, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Impact:

Enhances understanding of psoriasis for healthcare professionals, aiding in diagnosis and management.
Provides a foundation for evidence-based treatment decisions, potentially improving patient outcomes.
Contributes to the continuing education of medical professionals regarding this complex dermatological condition.