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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

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Related Experiment Video

Updated: Jun 19, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Translating evidence into practice.

David J Pierson1

  • 1Department of Respiratory Care, Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359762, Seattle, WA 98104, USA. djp@u.washington.edu

Respiratory Care
|October 3, 2009
PubMed
Summary
This summary is machine-generated.

Implementing evidence-based practices in respiratory care is crucial but faces significant barriers. Knowledge translation strategies are essential to bridge the gap between research findings and patient benefits, improving outcomes and optimizing healthcare.

Related Experiment Videos

Last Updated: Jun 19, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Area of Science:

  • Health Services Research
  • Respiratory Medicine
  • Knowledge Translation

Background:

  • Research and evidence-based guidelines are vital for improving patient care and health outcomes.
  • Significant gaps exist between available evidence and its application in clinical practice, particularly in respiratory care.
  • Key areas like chronic obstructive pulmonary disease (COPD) diagnosis (spirometry), noninvasive ventilation for acute respiratory failure, and lung-protective ventilation for acute lung injury/acute respiratory distress syndrome (ARDS) show suboptimal implementation despite proven benefits.

Purpose of the Study:

  • To discuss the challenges hindering the translation of research findings into clinical practice in respiratory care.
  • To provide examples of successful knowledge translation initiatives in respiratory medicine.
  • To outline necessary steps for realizing the full potential of available evidence for patients and the healthcare system.

Main Methods:

  • The paper reviews existing literature and discusses barriers to evidence-based practice adoption.
  • It examines challenges such as clinician awareness, guideline agreement, perceived complexity, patient factors, and the difficulty of changing established practices.
  • Case examples of successful knowledge translation in respiratory care are presented.

Main Results:

  • Despite strong evidence, critical respiratory care interventions like spirometry for COPD, noninvasive ventilation, and lung-protective ventilation are underutilized.
  • Multiple barriers, including clinician-related factors and practice complexities, impede the uptake of evidence-based guidelines.
  • Knowledge translation efforts are crucial for overcoming these barriers and integrating research into routine care.

Conclusions:

  • Effective knowledge translation is paramount to ensure patients benefit from advances in respiratory care.
  • Addressing barriers requires a comprehensive approach involving all aspects of healthcare delivery.
  • Successful implementation of evidence-based practices can optimize patient outcomes and healthcare system efficiency.