Brain dialysis of neurotransmitters: a commentary

Brain dialysis has become an important tool for investigating changes in the extracellular levels of neurotransmitters. This paper reviews the experimental variables and criteria that should be considered when interpreting data obtained with the brain dialysis method. Brain dialysis can provide important direct information on the effect of drugs on transmitter release as shown using dopaminergic agonists and antagonists, monoamine uptake inhibitors and drugs of abuse.