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CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner

Ashutosh Chaudhry1, Dipayan Rudra, Piper Treuting

  • 1Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Science (New York, N.Y.)
|October 3, 2009
PubMed
Summary

Regulatory T cells (Tregs) suppress pathogenic T helper 17 (Th17) immune responses by regulating STAT signaling. Loss of Treg-specific Stat3 impairs this suppression, leading to fatal inflammation.

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