Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predictable changes in low density lipoprotein composition after acute myocardial infarction.

A D Sniderman, B Teng

    Atherosclerosis
    |July 1, 1977
    PubMed
    Summary

    Myocardial infarction alters low-density lipoprotein (LDL) cholesterol levels by changing the cholesterol ester and triglyceride balance within LDL particles. This inverse relationship suggests a dynamic LDL composition following heart attacks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Research progress on the correlation between pediatric obstructive sleep apnea syndrome and obesity].

    Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2023
    Same author

    Using hemoglobin/fibrinogen ratio as earlier consumptive coagulopathy relating marker for a successful rescued amniotic fluid embolism case.

    Revista espanola de anestesiologia y reanimacion·2023
    Same author

    [The therapeutic effect of probiotics on allergic rhinitis：a Meta analysis].

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2018
    Same author

    Obstetric and neonatal outcomes after transfer of vitrified early cleavage embryos.

    Human reproduction (Oxford, England)·2013
    Same author

    Establishing cut-off values for apolipoprotein B and non-HDL-C according to LDL-C values in a South European population.

    International journal of clinical practice·2012
    Same author

    Formation of a planar optical waveguide by mega-electron-volt He+ and P+ ions implanted in a BiB(3)O(6) crystal.

    Optics letters·2007

    Area of Science:

    • Cardiovascular Medicine
    • Biochemistry
    • Lipid Metabolism

    Background:

    • Low-density lipoprotein (LDL) cholesterol levels can change rapidly, influenced by particle number or cholesterol content per particle.
    • Myocardial infarction (MI) is known to cause abrupt alterations in LDL cholesterol levels.

    Purpose of the Study:

    • To investigate the compositional changes within LDL particles following myocardial infarction.
    • To determine if changes in LDL cholesterol after MI are due to alterations in cholesterol ester and triglyceride content.

    Main Methods:

    • Analyzed LDL composition (B protein, free cholesterol, phospholipid, cholesterol ester, triglyceride) in nine MI patients.
    • Compared initial LDL composition with samples showing the greatest LDL cholesterol level changes during hospitalization.

    Related Experiment Videos

  • Utilized a pseudomicellar model to interpret findings.

    • Main Results:

    • No significant differences in B protein, free cholesterol, or phospholipid proportions were found.
    • A disproportionate decrease in cholesterol ester relative to triglyceride occurred when LDL cholesterol fell.
    • The opposite trend was observed when LDL cholesterol levels rose, showing an inverse relationship (Y = -1.02 X -0.17, r = -0.94).

    Conclusions:

    • LDL composition dynamically adjusts after myocardial infarction, primarily through inverse changes in cholesterol ester and triglyceride content.
    • These findings support a pseudomicellar model of LDL structure where the internal lipid core varies inversely with LDL concentration.